We are leaders in mouse transgenics and gene targeting, including CRISPR/Cas knockouts and gene edits.

    Place an order online by selecting the service you want from the menu at left or from the navigation bar at the bottom of the page.

    The Case Transgenic and Targeting Core Facility fees are low, our wait times are short and we have outstanding success rates with over 180 publications of transgenic and targeted mice resulting from our work.

    We are supported by the Case Western Reserve University School of Medicine and the Case Comprehensive Cancer Center.

Weihong JiangStaffWRB 2514368-2528
David LePageStaffWRB 2514368-2528
Rachel MannManagerWRB 2514368-2528
Ron ConlonDirectorBRB 623 368-1826

Get up to $10,000 for pilot projects using our services from the Clinical and Translational Science Collaborative.

Transgenic and Targeted Mice Made by the Core

  1. Bhattaram P, Penzo-Méndez A, Kato K, Bandyopadhyay K, Gadi A, Taketo MM, Lefebvre V. SOXC proteins amplify canonical WNT signaling to secure nonchondrocytic fates in skeletogenesis. J Cell Biol. 2014 PMID: 25452386

  2. Cerpa V, Gonzalez A, Richerson GB Diphtheria toxin treatment of Pet-1-Cre floxed diphtheria toxin receptor mice disrupts thermoregulation without affecting respiratory chemoreception. Neuroscience. 2014 279:65-76.

  3. Chen Z, Yue SX, Zhou G, Greenfield EM, Murakami S. ERK1 and ERK2 regulate chondrocyte terminal differentiation during endochondral bone formation. J Bone Miner Res. 2014 PMID: 25401279

  4. Ng HP, Zhou Y, Song K, Hodges CA, Drumm ML, Wang G. Neutrophil-mediated phagocytic host defense defect in myeloid cftr-inactivated mice. PLoS One. 2014 9(9):e106813. PMID: 25184794

  5. Khoriaty R, Vasievich MP, Jones M, Everett L, Chase J, Tao J, Siemieniak D, Zhang B, Maillard I, Ginsburg D. Absence of a red blood cell phenotype in mice with hematopoietic deficiency of SEC23B. Mol Cell Biol. 2014 PMID: 25071156

  6. Yin X, Kiryu-Seo S, Kidd GJ, Feltri ML, Wrabetz L, Trapp BD. Proteolipid protein cannot replace P0 protein as the major structural protein of peripheral nervous system myelin. Glia. 2014 PMID: 25066805

  7. Issler O, Haramati S, Paul ED, Maeno H, Navon I, Zwang R, Gil S, Mayberg HS, Dunlop BW, Menke A, Awatramani R, Binder EB, Deneris ES, Lowry CA, Chen A. MicroRNA 135 Is Essential for Chronic Stress Resiliency, Antidepressant Efficacy, and Intact Serotonergic Activity. 2014 Neuron. 6273(14)00486-3. PMID: 24952960

  8. Gresham KS, Mamidi R, Stelzer JE. The contribution of cMyBP-C Ser282 phosphorylation to the rate of force generation and in vivo cardiac contractility. J Physiol. 2014 PMID: 24951619

  9. Hinman MN, Sharma A, Luo G, Lou H. Neurofibromatosis Type 1 Alternative Splicing Is a Key Regulator of Ras Signaling in Neurons. Mol Cell Biol. 2014 34(12):2188-2197. PMID: 24710274

  10. Arachiche A, de la Fuente M, Nieman MT. Platelet Specific Promoters Are Insufficient to Express Protease Activated Receptor 1 (PAR1) Transgene in Mouse Platelets. PLoS One. 2014 9(5):e97724. PMID: 24830314

  11. Spoida K, Masseck OA, Deneris ES, Herlitze S. Gq/5-HT2c receptor signals activate a local GABAergic inhibitory feedback circuit to modulate serotonergic firing and anxiety in mice. Proc Natl Acad Sci U S A. 2014 PMID: 24733892

  12. Jacobsen CM, Barber LA, Ayturk UM, Roberts HJ, Deal LE, Schwartz MA, Weis M, Eyre D, Zurakowski D, Robling AG, Warman ML. Targeting the LRP5 Pathway Improves Bone Properties in a Mouse Model of Osteogenesis Imperfecta. J Bone Miner Res. 2014 PMID: 24677211

  1. Ouyang Z, Chen Z, Ishikawa M, Yue X, Kawanami A, Leahy P, Greenfield EM, Murakami S. Prx1 and 3.2kb Col1a1 promoters target distinct bone cell populations in transgenic mice. Bone. 2013 PMID: 24513582

  2. Ayturk UM, Jacobsen CM, Christodoulou DC, Gorham J, Seidman JG, Seidman CE, Robling AG, Warman ML. An RNA-seq protocol to identify mRNA expression changes in mouse diaphyseal bone: applications in mice with bone property altering Lrp5 mutations. J Bone Miner Res. 2013 28(10):2081-93. PMID: 23553928

  3. Waller KA, Zhang LX, Elsaid KA, Fleming BC, Warman ML, Jay GD. Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis. Proc Natl Acad Sci U S A. 2013 110(15):5852-7. PMID: 23530215

  4. Shi Q, Prior M, Zhou X, Tang X, He W, Hu X, Yan R. Preventing formation of reticulon 3 immunoreactive dystrophic neurites improves cognitive function in mice. J Neurosci. 2013 33(7):3059-66. PMID: 23407961

  5. Kedlaya R, Veera S, Horan DJ, Moss RE, Ayturk UM, Jacobsen CM, Bowen ME, Paszty C, Warman ML, Robling AG. Sclerostin Inhibition Reverses Skeletal Fragility in an Lrp5-Deficient Mouse Model of OPPG Syndrome. Sci Transl Med. 2013 5(211):211ra158. PMID: 24225945

  6. Luo X, He W, Hu X, Yan R. Reversible Overexpression of Bace1-Cleaved Neuregulin-1 N-Terminal Fragment Induces Schizophrenia-Like Phenotypes in Mice. Biol Psychiatry. 2013 PMID: 24210810

  7. Yeh IJ, Ogba N, Bensigner H, Welford SM, Montano MM. HEXIM1 down-regulates hypoxia-inducible factor-1α protein stability. Biochem J. 2013 456(2):195-204 PMID: 24015760

  8. Zhang H, Alberich-Jorda M, Amabile G, Yang H, Staber PB, Diruscio A, Welner RS, Ebralidze A, Zhang J, Levantini E, Lefebvre V, Valk PJ, Delwel R, Hoogenkamp M, Nerlov C, Cammenga J, Saez B, Scadden DT, Bonifer C, Ye M, Tenen DG. Sox4 Is a Key Oncogenic Target in C/EBPα Mutant Acute Myeloid Leukemia. Cancer Cell. 2013 PMID: 24183681

  9. Bükülmez H, Khan F, Bartels CF, Murakami S, Ortiz-Lopez A, Sattar A, Haqqi TM, Warman ML. Protective effects of C-type natriuretic peptide on linear growth and articular cartilage integrity in an inflammatory arthritis mouse model. Arthritis Rheum. 2013 PMID: 24114569

  10. Yuan J, Zhan YA, Abskharon R, Xiao X, Martinez MC, Zhou X, Kneale G, Mikol J, Lehmann S, Surewicz WK, Castilla J, Steyaert J, Zhang S, Kong Q, Petersen RB, Wohlkonig A, Zou WQ. Recombinant Human Prion Protein Inhibits Prion Propagation in vitro. Sci Rep. 2013 Oct 9;3:2911. PMID: 24105336

  11. Ninkovic J, Steiner-Mezzadri A, Jawerka M, Akinci U, Masserdotti G, Petricca S, Fischer J, von Holst A, Beckers J, Lie CD, Petrik D, Miller E, Tang J, Wu J, Lefebvre V, Demmers J, Eisch A, Metzger D, Crabtree G, Irmler M, Poot R, Götz M. The BAF Complex Interacts with Pax6 in Adult Neural Progenitors to Establish a Neurogenic Cross-Regulatory Transcriptional Network. Cell Stem Cell. 2013 PMID: 23933087

  12. Ohta S, Misawa A, Lefebvre V, Okano H, Kawakami Y, Toda M. Sox6 up-regulation by macrophage migration inhibitory factor promotes survival and maintenance of mouse neural stem/progenitor cells. PLoS One. 2013 Sep 16;8(9):e74315. PMID: 24066135

  13. Liu L, Li M, Spangler LC, Spear C, Veenstra M, Darnall L, Chang C, Cotleur AC, Ransohoff RM. Functional defect of peripheral neutrophils in mice with induced deletion of CXCR2. Genesis. 2013 PMID: 23650205

  14. DePuy SD, Stornetta RL, Bochorishvili G, Deisseroth K, Witten I, Coates M, Guyenet PG. Glutamatergic neurotransmission between the C1 neurons and the parasympathetic preganglionic neurons of the dorsal motor nucleus of the vagus. J Neurosci. 2013 33(4):1486-97. PMID: 23345223

  15. Zechel JL, Doerner SK, Lager A, Tesar PJ, Heaney JD, Nadeau JH. Contrasting effects of Deadend1 (Dnd1) gain and loss of function mutations on allelic inheritance, testicular cancer, and intestinal polyposis. BMC Genet. 2013 14:54. PMID: 23773267

  16. He X, Arrotta N, Radhakrishnan D, Wang Y, Romigh T, Eng C. Cowden Syndrome-Related Mutations in PTEN Associate with Enhanced Proteasome Activity. Cancer Res. 2013 73(10):3029-40 PMID: 23475934

  17. Malhotra N, Narayan K, Cho OH, Sylvia KE, Yin C, Melichar H, Rashighi M, Lefebvre V, Harris JE, Berg LJ, Kang J; Immunological Genome Project Consortium. 2013 A network of high-mobility group box transcription factors programs innate interleukin-17 production. Immunity. 38(4):681-93. PMID: 23562159

  18. Jiang Y, Ding Q, Xie X, Libby R, Lefebvre V, Gan L. 2013 Transcription factors SOX4 and SOX11 function redundantly to regulate the development of mouse retinal ganglion cells. J Biol Chem 288(25):18429-38 PMID: 23649630

  19. Montano MM, Desjardins C, Doughman YQ, Hsieh YH, Hu Y, Bensinger H, Wang C, Stelzer J, Dick T, Hoit B, Chandler MP, Yu X, Watanabe M. (2013) Inducible reexpression of HEXIM1 causes physiological cardiac hypertrophy in the adult mouse. Cardiovasc Res. PMID: 23585471

  20. Kiyasova V, Bonnavion P, Scotto-Lomassese S, Fabre V, Sahly I, Tronche F, Deneris E, Gaspar P, Fernandez SP. A subpopulation of serotonergic neurons that do not express the 5-HT1A autoreceptor. ACS Chem Neurosci. 2013 4(1):89-95 PMID: 23336048

  21. Narboux-Nême N, Angenard G, Mosienko V, Klempin F, Pitychoutis PM, Deneris E, Bader M, Giros B, Alenina N, Gaspar P. Postnatal growth defects in mice with constitutive depletion of central serotonin. ACS Chem Neurosci. 2013 4(1):171-81 PMID: 23336056

  22. Sun B, Mallampati S, Gong Y, Wang D, Lefebvre V, Sun X. Sox4 is required for the survival of pro-B cells. J Immunol. 2013 190(5):2080-9. 2013 PMID: 23345330

  23. Mead TJ, Wang Q, Bhattaram P, Dy P, Afelik S, Jensen J, Lefebvre V. A far-upstream (-70 kb) enhancer mediates Sox9 auto-regulation in somatic tissues during development and adult regeneration. Nucleic Acids Res. 2013 PMID: 23449223