SOM     CCCC     CTSC
    We are leaders in transgenics, gene targeting and CRISPR/Cas-mediated mutagenesis in mice. We can design and validate your CRISPR/Cas targeting strategy, and generate mutant mice quickly.

     Our fees are low, our wait times are short and our success rates are high. New transgenic and targeted mice that we have created are featured in over 200 publications since 2004.

    The Case Transgenic and Targeting Facility is supported by the Case Western Reserve University School of Medicine the Case Comprehensive Cancer Center and the Clinical and Translational Science Collaborative, which has a pilot project grant program for our services, including CRISPR/Cas mutagenesis.

NameRoleOfficePhone
Weihong JiangStaffWRB 2514368-2528
David LePageStaffWRB 2514368-2528
Rachel MannManagerWRB 2514368-2528
Ron ConlonDirectorBRB 623 368-1826


ctsc
Get up to $10,000 for pilot projects using our services from the Clinical and Translational Science Collaborative.

Transgenic and Targeted Mice Made by the Core

2015
  1. Seaberg B, Henslee G, Wang S, Paez-Colasante X, Landreth GE, Rimer M. Muscle-derived ERK1/2 MAP kinases are required for the maintenance of adult myofibers and their neuromuscular junctions. Mol Cell Biol. 2015 PMID: 25605336

  2. Berisha SZ, Brubaker G, Kasumov T, Hung KT, DiBello PM, Huang Y, Li L, Willard B, Pollard KA, Nagy LE, Hazen SL, Smith JD. HDL from ApoA1 Transgenic Mice Expressing the 4WF Isoform Is Resistant to Oxidative Loss of Function. J Lipid Res. 2015 PMID: 25561462

  3. Afelik S, Pool B, Schmerr M, Penton C, Jensen J. Wnt7b is required for epithelial progenitor growth and operates during epithelial-to-mesenchymal signaling in pancreatic development. Dev Biol. 2015 PMID: 25576928

2014
  1. Tilot AK, Gaugler MK, Yu Q, Romigh T, Yu W, Miller RH, Frazier TW 2nd, Eng C. Germline disruption of Pten localization causes enhanced sex-dependent social motivation and increased glial production. Hum Mol Genet. 2014 23(12):3212-27. PMID: 24470394

  2. Bhattaram P, Penzo-Méndez A, Kato K, Bandyopadhyay K, Gadi A, Taketo MM, Lefebvre V. SOXC proteins amplify canonical WNT signaling to secure nonchondrocytic fates in skeletogenesis. J Cell Biol. 2014 PMID: 25452386

  3. Cerpa V, Gonzalez A, Richerson GB Diphtheria toxin treatment of Pet-1-Cre floxed diphtheria toxin receptor mice disrupts thermoregulation without affecting respiratory chemoreception. Neuroscience. 2014 279:65-76.

  4. Chen Z, Yue SX, Zhou G, Greenfield EM, Murakami S. ERK1 and ERK2 regulate chondrocyte terminal differentiation during endochondral bone formation. J Bone Miner Res. 2014 PMID: 25401279

  5. Ng HP, Zhou Y, Song K, Hodges CA, Drumm ML, Wang G. Neutrophil-mediated phagocytic host defense defect in myeloid cftr-inactivated mice. PLoS One. 2014 9(9):e106813. PMID: 25184794

  6. Khoriaty R, Vasievich MP, Jones M, Everett L, Chase J, Tao J, Siemieniak D, Zhang B, Maillard I, Ginsburg D. Absence of a red blood cell phenotype in mice with hematopoietic deficiency of SEC23B. Mol Cell Biol. 2014 PMID: 25071156

  7. Yin X, Kiryu-Seo S, Kidd GJ, Feltri ML, Wrabetz L, Trapp BD. Proteolipid protein cannot replace P0 protein as the major structural protein of peripheral nervous system myelin. Glia. 2014 PMID: 25066805

  8. Issler O, Haramati S, Paul ED, Maeno H, Navon I, Zwang R, Gil S, Mayberg HS, Dunlop BW, Menke A, Awatramani R, Binder EB, Deneris ES, Lowry CA, Chen A. MicroRNA 135 Is Essential for Chronic Stress Resiliency, Antidepressant Efficacy, and Intact Serotonergic Activity. 2014 Neuron. 6273(14)00486-3. PMID: 24952960

  9. Gresham KS, Mamidi R, Stelzer JE. The contribution of cMyBP-C Ser282 phosphorylation to the rate of force generation and in vivo cardiac contractility. J Physiol. 2014 PMID: 24951619

  10. Hinman MN, Sharma A, Luo G, Lou H. Neurofibromatosis Type 1 Alternative Splicing Is a Key Regulator of Ras Signaling in Neurons. Mol Cell Biol. 2014 34(12):2188-2197. PMID: 24710274

  11. Arachiche A, de la Fuente M, Nieman MT. Platelet Specific Promoters Are Insufficient to Express Protease Activated Receptor 1 (PAR1) Transgene in Mouse Platelets. PLoS One. 2014 9(5):e97724. PMID: 24830314

  12. Spoida K, Masseck OA, Deneris ES, Herlitze S. Gq/5-HT2c receptor signals activate a local GABAergic inhibitory feedback circuit to modulate serotonergic firing and anxiety in mice. Proc Natl Acad Sci U S A. 2014 PMID: 24733892

  13. Jacobsen CM, Barber LA, Ayturk UM, Roberts HJ, Deal LE, Schwartz MA, Weis M, Eyre D, Zurakowski D, Robling AG, Warman ML. Targeting the LRP5 Pathway Improves Bone Properties in a Mouse Model of Osteogenesis Imperfecta. J Bone Miner Res. 2014 PMID: 24677211